![]() Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane.įor 60 mg and 120 mg: Meets USP Dissolution Test 1. ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of about 90☌, and an optical rotation of +144° (2% in water, 20☌). ![]() The chemical name for ISMN is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate the compound has the following structural formula: The molecular formula of ISMN is C6H9NO6 and the molecular weight is 191.14. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, diethyl phthalate, hydrogenated castor oil, hydroxypropyl cellulose, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, talc and titanium dioxide. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.Įach tablet, for oral administration, contains either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation.
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